Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | BCL3 | P20749 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20180830 | 0.87 | NPC1 (0.48) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL20167669 | 0.87 | NPC1 (0.48) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL20167556 | 0.79 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL21376332 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL20180831 | 0.79 | NPC1 (0.55) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL20167853 | 0.79 | HPGD (0.51) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL18927598 | 0.69 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL20207639 | 0.68 | GAA (0.41) | SMN1; SMN2NPC1NPSR1RAB9AHPGD | |
| SCHEMBL21222487 | 0.67 | HPGD (0.51) | SMN1; SMN2NPC1HPGDALDH1A1KMT2A | |
| SCHEMBL21222482 | 0.67 | KMT2A (0.51) | SMN1; SMN2NPC1NPSR1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093579-A1 | TRIAZOLE PHENYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-24 | — | — | WO | disclosed |