Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | RBBP9 | O75884 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20207359 | 0.88 | GAA (0.41) | GAARAB9ANPC1ADRB2GRM4 | |
| SCHEMBL20189542 | 0.88 | GAA (0.41) | GAARAB9ANPC1ADRB2GRM4 | |
| SCHEMBL20189540 | 0.88 | GAA (0.41) | GAARAB9ANPC1ADRB2GRM4 | |
| SCHEMBL20188746 | 0.81 | GRM4 (0.52) | GAARAB9ANPC1ADRB2GRM4 | |
| SCHEMBL20190237 | 0.81 | GAA (0.43) | GAARAB9ANPC1ADRB2GRM4 | |
| SCHEMBL20207357 | 0.81 | GAA (0.43) | GAARAB9ANPC1ADRB2GRM4 | |
| SCHEMBL15111138 | 0.69 | SMN1; SMN2 (0.47) | GAARAB9ANPC1GRM4KMT2A | |
| SCHEMBL20180716 | 0.68 | SMN1; SMN2 (0.49) | GAARAB9ANPC1KMT2AMEN1 | |
| SCHEMBL723820 | 0.66 | RORC (0.53) | GAARAB9ANPC1ADRB2GRM4 | |
| SCHEMBL20775422 | 0.65 | NLRP3 (0.61) | GAARAB9ANPC1ADRB2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018097945-A1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |