Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BCL3 | P20749 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20167669 | 1.00 | NPC1 (0.48) | NPC1SMN1; SMN2KAT6ARAB9AHPGD | |
| SCHEMBL20180716 | 0.87 | SMN1; SMN2 (0.49) | NPC1SMN1; SMN2KAT6ARAB9AHPGD | |
| SCHEMBL18927598 | 0.79 | SMN1; SMN2 (0.41) | NPC1SMN1; SMN2RAB9AHPGDALDH1A1 | |
| SCHEMBL20167556 | 0.78 | SMN1; SMN2 (0.68) | NPC1SMN1; SMN2KAT6ARAB9AHPGD | |
| SCHEMBL21376332 | 0.78 | SMN1; SMN2 (0.51) | NPC1SMN1; SMN2KAT6ARAB9AHPGD | |
| SCHEMBL20167853 | 0.78 | HPGD (0.51) | NPC1SMN1; SMN2KAT6ARAB9AHPGD | |
| SCHEMBL20180831 | 0.78 | NPC1 (0.55) | NPC1SMN1; SMN2KAT6ARAB9AHPGD | |
| SCHEMBL20385129 | 0.76 | HPGD (0.50) | NPC1SMN1; SMN2RAB9AHPGDALDH1A1 | |
| SCHEMBL11653906 | 0.72 | SIGMAR1 (0.49) | SMN1; SMN2RAB9AHPGDALDH1A1KDM4E | |
| SCHEMBL11653902 | 0.72 | SIGMAR1 (0.49) | SMN1; SMN2RAB9AHPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541810-B1 | TRIAZOLE PHENYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2018093579-A1 | TRIAZOLE PHENYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-24 | — | — | WO | disclosed |