Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 12/20 | 0.46 |
| ▸ | RXRA | P19793 | 7/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19412876 | 0.85 | NOTUM (0.39) | NOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL16982961 | 0.83 | NOTUM (0.49) | NOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL19412843 | 0.81 | NOTUM (0.53) | NOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL17661867 | 0.80 | NOTUM (0.46) | NOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL23612791 | 0.79 | NOTUM (0.34) | NOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL18710682 | 0.78 | NOTUM (0.44) | NOTUM | |
| SCHEMBL19412877 | 0.77 | GABRA2 (0.41) | NOTUMRXRAGRIN1GRIN2BP2RX7 | |
| SCHEMBL19412858 | 0.77 | GRM5 (0.34) | P2RX7 | |
| SCHEMBL19412818 | 0.76 | NOTUM (0.56) | NOTUM | |
| SCHEMBL20181106 | 0.74 | NOTUM (0.42) | NOTUMP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10676477-B2 | Factor XIa macrocycle inhibitors bearing a non-aromatic P2' group | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-06-09 | — | — | US | disclosed |
| US-20190144393-A1 | FACTOR XIA MACROCYCLES WITH NOVEL P1 GROUPS | BRISTOL MYERS SQUIBB CO (US) | 2019-05-16 | — | — | US | disclosed |
| US-10287288-B2 | Factor XIa macrocyclic inhibitors bearing alkyl or cycloalkyl P2' moieties | BRISTOL-MYERS SQUIBB (US) | 2019-05-14 | — | — | US | disclosed |
| US-20180215755-A1 | FACTOR XIA MACROCYCLIC INHIBITORS BEARING ALKYL OR CYCLOALKYL P2' MOIETIES | BRISTOL MYERS SQUIBB CO (US) | 2018-08-02 | — | — | US | disclosed |
| US-20180141932-A1 | DIAMIDE MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141932-A1 | DIAMIDE MACROCYCLES AS FACTOR XIA INHIBITORS | TFPI, TFPI2, F11 | NOTUM 3242/4885RXRA 4578/4885GRIN1 4581/4885 |
| US-20180215755-A1 | FACTOR XIA MACROCYCLIC INHIBITORS BEARING ALKYL OR CYCLOALKYL P2' MOIETIES | TFPI, TFPI2, F11 | NOTUM 3040/4885RXRA 4563/4885GRIN1 4473/4885 |
| US-20190144393-A1 | FACTOR XIA MACROCYCLES WITH NOVEL P1 GROUPS | F11, F12, TFPI | NOTUM 2881/4885RXRA 4383/4885GRIN1 3969/4885 |
| US-10676477-B2 | Factor XIa macrocycle inhibitors bearing a non-aromatic P2' group | TFPI, TFPI2, F2 | NOTUM 2986/4885RXRA 4270/4885GRIN1 4685/4885 |
| US-10287288-B2 | Factor XIa macrocyclic inhibitors bearing alkyl or cycloalkyl P2' moieties | TFPI, TFPI2, F11 | NOTUM 3040/4885RXRA 4563/4885GRIN1 4473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.