Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 5/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.31 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31324432 | 0.84 | APLNR (0.35) | APLNRSCN5ASCN10ASMN1; SMN2ACACB | |
| SCHEMBL18253945 | 0.81 | APLNR (0.44) | APLNR | |
| SCHEMBL19573889 | 0.81 | APLNR (0.44) | APLNR | |
| SCHEMBL18647959 | 0.76 | NPC1 (0.35) | SCN5ASCN10ASMN1; SMN2ACACBALDH1A1 | |
| SCHEMBL18948134 | 0.72 | NPC1 (0.33) | SMN1; SMN2ACACBNPC1RAB9AHSD17B10 | |
| SCHEMBL1331883 | 0.72 | NPC1 (0.33) | SMN1; SMN2ACACBNPC1RAB9AHSD17B10 | |
| SCHEMBL20190471 | 0.70 | APLNR (0.40) | APLNRSMN1; SMN2 | |
| SCHEMBL20188474 | 0.69 | APLNR (0.35) | APLNRNPC1RAB9A | |
| SCHEMBL20200283 | 0.69 | APLNR (0.35) | APLNRNPC1RAB9A | |
| SCHEMBL20188472 | 0.69 | APLNR (0.35) | APLNRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093580-A1 | TRIAZOLE PYRIDYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-24 | — | — | WO | disclosed |