Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20200283 | 1.00 | APLNR (0.35) | APLNRNPC1RAB9AKDM4E | |
| SCHEMBL20188472 | 1.00 | APLNR (0.35) | APLNRNPC1RAB9AKDM4E | |
| SCHEMBL20190471 | 0.84 | APLNR (0.40) | APLNRKDM4E | |
| SCHEMBL20188717 | 0.82 | APLNR (0.35) | APLNRNPC1RAB9AKDM4E | |
| SCHEMBL20188719 | 0.82 | APLNR (0.35) | APLNRNPC1RAB9AKDM4E | |
| SCHEMBL20190068 | 0.78 | APLNR (0.39) | APLNRNPC1RAB9AKDM4E | |
| SCHEMBL20189305 | 0.78 | APLNR (0.39) | APLNRNPC1RAB9AKDM4E | |
| SCHEMBL20189301 | 0.78 | APLNR (0.39) | APLNRNPC1RAB9AKDM4E | |
| SCHEMBL2629015 | 0.74 | KDM4E (0.39) | NPC1RAB9AKDM4E | |
| SCHEMBL20181306 | 0.69 | APLNR (0.36) | APLNRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541792-B1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3541792-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | Amgen Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018097944-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018097944-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |