Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 11/20 | 0.39 |
| ▸ | EYA3 | Q99504 | 3/20 | 0.39 |
| ▸ | TTR | P02766 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | EYA2 | O00167 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18629847 | 0.90 | SLC22A12 (0.43) | SLC22A12EYA3TTRALDH1A1MAPK1 | |
| SCHEMBL18629835 | 0.89 | RAB9A (0.44) | SLC22A12EYA3TTRALDH1A1MAPK1 | |
| SCHEMBL18629846 | 0.86 | SLC22A12 (0.47) | SLC22A12EYA3TTRALDH1A1MAPK1 | |
| SCHEMBL18629885 | 0.85 | SLC22A12 (0.38) | SLC22A12EYA3TTRALDH1A1MAPK1 | |
| SCHEMBL18629888 | 0.85 | SLC22A12 (0.37) | SLC22A12EYA3TTRALDH1A1MAPK1 | |
| SCHEMBL18629839 | 0.84 | MAPK1 (0.46) | SLC22A12EYA3TTRALDH1A1MAPK1 | |
| SCHEMBL21176882 | 0.83 | SLC22A12 (0.37) | SLC22A12EYA3TTRALDH1A1MAPK1 | |
| SCHEMBL18629791 | 0.83 | CYP3A4 (0.39) | SLC22A12EYA3TTRALDH1A1MAPK1 | |
| SCHEMBL18629881 | 0.81 | CYP2C9 (0.42) | SLC22A12EYA3TTRALDH1A1MAPK1 | |
| SCHEMBL20181391 | 0.81 | LMNA (0.49) | SLC22A12ALDH1A1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543240-B1 | URAT1 INHIBITOR AND USE THEREOF | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3543240-A1 | URAT1 INHIBITOR AND USE THEREOF | Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd. (CN) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018090921-A1 | URAT1 INHIBITOR AND USE THEREOF | 江苏新元素医药科技有限公司 | 2018-05-24 | — | — | WO | disclosed |