Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.74 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.48 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.48 |
| ▸ | PRKG1 | Q13976 | 5/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.47 |
| ▸ | CDK1 | P06493 | 3/20 | 0.47 |
| ▸ | PRKACA | P17612 | 3/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | GSK3A | P49840 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | PRKX | P51817 | 3/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.47 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20181611 | 0.88 | ROCK1 (0.57) | ROCK2ROCK1ADORA3ADORA2AADORA2B | |
| SCHEMBL20181589 | 0.87 | MAPK1 (0.64) | ROCK2ROCK1ADORA3ADORA2AADORA2B | |
| SCHEMBL18249504 | 0.85 | ROCK1 (0.68) | ROCK2ROCK1ADORA3ADORA2AADORA2B | |
| SCHEMBL18254900 | 0.85 | ROCK2 (1.00) | ROCK2ROCK1MAPK1MAPK3PRKG1 | |
| SCHEMBL20181593 | 0.79 | MAPT (0.58) | ROCK2ROCK1ADORA3ADORA2AADORA2B | |
| SCHEMBL18254881 | 0.75 | ROCK1 (0.75) | ROCK2ROCK1MAPK1CYP3A4 | |
| SCHEMBL13986985 | 0.75 | GSK3B (0.58) | ROCK2ROCK1MAPK1PRKG1RPS6KA5 | |
| SCHEMBL13986994 | 0.74 | MAPK1 (0.56) | ROCK2ROCK1ADORA3ADORA2AADORA2B | |
| SCHEMBL2554179 | 0.74 | ROCK1 (1.00) | ROCK2ROCK1PRKACA | |
| SCHEMBL14739317 | 0.74 | ROCK1 (1.00) | ROCK2ROCK1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10807966-B2 | Heterocyclic compounds as kinase inhibitors | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2020-10-20 | — | — | US | disclosed |
| US-20190284157-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2019-09-19 | — | — | US | disclosed |
| WO-2018094362-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10807966-B2 | Heterocyclic compounds as kinase inhibitors | MAP3K1, MAP3K20, MAP3K5 | ROCK2 76/4885ROCK1 67/4885ADORA3 2468/4885 |
| US-20190284157-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | MAP3K1, MAP3K20, MAP3K5 | ROCK2 76/4885ROCK1 67/4885ADORA3 2468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.