Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | ALPL | P05186 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | ACR | P10323 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13987009 | 0.87 | GSK3B (0.54) | MAPTLMNAALDH1A1ALPLNPC1 | |
| SCHEMBL20181611 | 0.80 | ROCK1 (0.57) | ROCK1ROCK2ADORA3ADORA2AADORA2B | |
| SCHEMBL20181599 | 0.79 | ROCK2 (0.74) | ROCK1ROCK2ADORA3ADORA2AADORA2B | |
| SCHEMBL20181589 | 0.79 | MAPK1 (0.64) | ALPLROCK1ROCK2ADORA3ADORA2A | |
| SCHEMBL3109362 | 0.78 | ROCK1 (0.74) | ALDH1A1ROCK1ROCK2PRKG1GSK3A | |
| SCHEMBL13986991 | 0.76 | ROCK1 (0.63) | ROCK1ROCK2PRKG1GSK3AGSK3B | |
| SCHEMBL29033909 | 0.75 | RAB9A (0.55) | MAPTLMNAALDH1A1ALPLNPC1 | |
| SCHEMBL3110316 | 0.75 | ROCK1 (0.59) | ROCK1ROCK2PRKG1GSK3AGSK3B | |
| SCHEMBL3102089 | 0.75 | ROCK1 (0.58) | MAPTALDH1A1SMN1; SMN2ROCK1ROCK2 | |
| SCHEMBL3104229 | 0.75 | ROCK1 (0.59) | ROCK1ROCK2PRKG1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10807966-B2 | Heterocyclic compounds as kinase inhibitors | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2020-10-20 | — | — | US | disclosed |
| US-20190284157-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2019-09-19 | — | — | US | disclosed |
| WO-2018094362-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10807966-B2 | Heterocyclic compounds as kinase inhibitors | MAP3K1, MAP3K20, MAP3K5 | MAPT 2045/4885LMNA 2623/4885ALDH1A1 2699/4885 |
| US-20190284157-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | MAP3K1, MAP3K20, MAP3K5 | MAPT 2045/4885LMNA 2623/4885ALDH1A1 2699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.