Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20181300 | 0.81 | KDM4E (0.32) | KDM4ECYP2D6CYP2C19BLMNPSR1 | |
| SCHEMBL27470417 | 0.78 | PMP22 (0.35) | PMP22KDM4ECYP2C19BLMTP53 | |
| SCHEMBL8515868 | 0.78 | PMP22 (0.35) | PMP22KDM4ECYP2C19BLMTP53 | |
| SCHEMBL27635838 | 0.73 | PMP22 (0.35) | PMP22CYP2D6CYP2C19 | |
| SCHEMBL10425679 | 0.71 | — | — | |
| SCHEMBL7354948 | 0.70 | SLC22A6 (0.39) | PMP22 | |
| SCHEMBL5689593 | 0.70 | SLC22A6 (0.39) | PMP22 | |
| SCHEMBL16232092 | 0.70 | ALDH1A1 (0.50) | PMP22 | |
| SCHEMBL295045 | 0.68 | — | — | |
| SCHEMBL27905526 | 0.67 | TP53 (0.34) | PMP22TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3300500-B9 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2021-01-13 | — | — | EP | disclosed |
| EP-3300500-B1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-02-26 | — | — | EP | disclosed |
| WO-2018097945-A1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018093580-A1 | TRIAZOLE PYRIDYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-24 | — | — | WO | disclosed |