Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | AHR | P35869 | 3/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.59 |
| ▸ | RBP4 | P02753 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29806029 | 1.00 | FLT3 (0.69) | FLT3ALDH1A1MAPTAHRMAPK10 | |
| SCHEMBL21855639 | 0.87 | FLT3 (0.65) | FLT3ALDH1A1MAPTAHRMAPK10 | |
| SCHEMBL6114106 | 0.85 | FLT3 (0.67) | FLT3ALDH1A1MAPTAHRMAPK10 | |
| SCHEMBL28477124 | 0.84 | ALDH1A1 (0.60) | FLT3ALDH1A1MAPTAHRRBP4 | |
| SCHEMBL13779981 | 0.83 | FLT3 (0.69) | FLT3ALDH1A1MAPTAHRMAPK10 | |
| SCHEMBL26715294 | 0.83 | ALDH1A1 (0.59) | FLT3ALDH1A1MAPTAHRRBP4 | |
| SCHEMBL30861056 | 0.81 | JAK2 (0.53) | FLT3ALDH1A1MAPTAHRRBP4 | |
| SCHEMBL11970954 | 0.81 | HSP90AA1 (0.50) | FLT3ALDH1A1MAPTRBP4KMT2A | |
| SCHEMBL27228504 | 0.81 | JAK2 (0.53) | FLT3ALDH1A1MAPTAHRRBP4 | |
| SCHEMBL23244263 | 0.80 | ALDH1A1 (0.77) | FLT3ALDH1A1MAPTRBP4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541817-B1 | IMIDAZOPYRIDAZINE MODULATORS OF IL-12, IL-23 AND/OR IFN-ALPHA | BRISTOL MYERS SQUIBB CO (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2018093968-A1 | IMIDAZOPYRIDAZINE MODULATORS OF IL-12, IL-23 AND/OR IFN-ALPHA | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-24 | — | — | WO | disclosed |