Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 4/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14314019 | 0.90 | KDM4E (0.65) | KDM4ESMN1; SMN2YTHDC1NPC1RAB9A | |
| SCHEMBL30068590 | 0.88 | KDM4E (0.62) | KDM4ESMN1; SMN2YTHDC1NPC1RAB9A | |
| SCHEMBL30644770 | 0.81 | KDM4E (0.67) | KDM4ESMN1; SMN2YTHDC1NPC1RAB9A | |
| SCHEMBL20287865 | 0.81 | KDM4E (0.67) | KDM4ESMN1; SMN2YTHDC1NPC1RAB9A | |
| SCHEMBL10258485 | 0.80 | SMN1; SMN2 (0.60) | KDM4ESMN1; SMN2YTHDC1NPC1RAB9A | |
| SCHEMBL6360185 | 0.80 | KDM4E (0.75) | KDM4ESMN1; SMN2YTHDC1NPC1RAB9A | |
| SCHEMBL23854779 | 0.80 | YTHDC1 (0.69) | KDM4ESMN1; SMN2YTHDC1NPC1RAB9A | |
| SCHEMBL7846799 | 0.79 | SMN1; SMN2 (0.60) | KDM4ESMN1; SMN2YTHDC1NPC1RAB9A | |
| SCHEMBL4464788 | 0.79 | KDM4E (0.78) | KDM4ESMN1; SMN2YTHDC1NPC1RAB9A | |
| SCHEMBL952028 | 0.78 | SMN1; SMN2 (0.77) | KDM4ESMN1; SMN2YTHDC1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541817-B1 | IMIDAZOPYRIDAZINE MODULATORS OF IL-12, IL-23 AND/OR IFN-ALPHA | BRISTOL MYERS SQUIBB CO (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2018093968-A1 | IMIDAZOPYRIDAZINE MODULATORS OF IL-12, IL-23 AND/OR IFN-ALPHA | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-24 | — | — | WO | disclosed |