Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8373049 | 0.86 | SMN1; SMN2 (0.63) | SMN1; SMN2KDM4EMAPK10HSD17B10NPC1 | |
| SCHEMBL951202 | 0.86 | FLT3 (0.67) | SMN1; SMN2KDM4EMAPK10HSD17B10NPC1 | |
| SCHEMBL952028 | 0.85 | SMN1; SMN2 (0.77) | SMN1; SMN2KDM4EMAPK10HSD17B10NPC1 | |
| SCHEMBL952273 | 0.82 | KDM4E (0.68) | SMN1; SMN2KDM4EMAPK10HSD17B10NPC1 | |
| SCHEMBL14314019 | 0.80 | KDM4E (0.65) | SMN1; SMN2KDM4EMAPK10HSD17B10NPC1 | |
| SCHEMBL20181950 | 0.79 | KDM4E (0.64) | SMN1; SMN2KDM4EMAPK10HSD17B10NPC1 | |
| SCHEMBL30068590 | 0.78 | KDM4E (0.62) | SMN1; SMN2KDM4EMAPK10HSD17B10NPC1 | |
| SCHEMBL4525874 | 0.77 | ALDH1A1 (0.61) | SMN1; SMN2KDM4EMAPK10HSD17B10NPC1 | |
| SCHEMBL5945611 | 0.77 | FLT3 (0.69) | SMN1; SMN2KDM4ENPC1RAB9AYTHDC1 | |
| SCHEMBL954666 | 0.76 | KDM4E (0.64) | SMN1; SMN2KDM4EMAPK10HSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8377945-B2 | Small molecule inhibitors of spleen tyrosine kinase (SYK) | RIGEL PHARMACEUTICALS INC. (US) | 2013-02-19 | — | — | US | disclosed |
| US-20100316649-A1 | SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | MIDCAP FINANCIAL TRUST | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100316649-A1 | SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | SYK, BTK, LCK | SMN1; SMN2 2568/4885KDM4E 1205/4885MAPK10 647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.