Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 11/20 | 0.37 |
| ▸ | SRC | P12931 | 6/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20173329 | 0.89 | EIF2AK3 (0.38) | EIF2AK3SRCLCKTEK | |
| SCHEMBL20181911 | 0.86 | EIF2AK3 (0.37) | EIF2AK3SRCLCKTEK | |
| SCHEMBL20182194 | 0.82 | EIF2AK3 (0.36) | EIF2AK3SRCLCKTEK | |
| SCHEMBL20182190 | 0.80 | CFTR (0.35) | — | |
| SCHEMBL20182264 | 0.79 | SRC (0.35) | EIF2AK3SRCLCKTEKFLT3 | |
| SCHEMBL20182281 | 0.76 | FLT3 (0.39) | EIF2AK3SRCFLT3 | |
| SCHEMBL20182289 | 0.76 | NTRK1 (0.36) | EIF2AK3SRCTEKFLT3 | |
| SCHEMBL20182235 | 0.76 | EIF2AK3 (0.34) | EIF2AK3SRCTEKFLT3 | |
| SCHEMBL20181916 | 0.72 | CFTR (0.39) | EIF2AK3SRCLCKTEK | |
| SCHEMBL30037231 | 0.72 | CFTR (0.44) | EIF2AK3SRCLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |