Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20181911 | 0.80 | EIF2AK3 (0.37) | — | |
| SCHEMBL20182196 | 0.80 | EIF2AK3 (0.37) | — | |
| SCHEMBL20173329 | 0.80 | EIF2AK3 (0.38) | — | |
| SCHEMBL20181916 | 0.74 | CFTR (0.39) | CFTR | |
| SCHEMBL20162810 | 0.73 | CFTR (0.49) | CFTR | |
| SCHEMBL20182264 | 0.72 | SRC (0.35) | — | |
| SCHEMBL20181906 | 0.72 | EIF2AK3 (0.34) | CFTR | |
| SCHEMBL20162988 | 0.67 | CFTR (0.57) | CFTR | |
| SCHEMBL30538073 | 0.67 | CFTR (0.57) | CFTR | |
| SCHEMBL20182265 | 0.67 | NTRK1 (0.36) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |