Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PRKDC | P78527 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | PRKACA | P17612 | 2/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20181888 | 0.82 | ADK (0.44) | ADKFLT3SRCKDM4E | |
| SCHEMBL20162903 | 0.82 | FLT3 (0.56) | ADKFLT3PIK3CDPRKDCDYRK1A | |
| SCHEMBL20182182 | 0.79 | DYRK1A (0.32) | DYRK1AADORA2AADORA1 | |
| SCHEMBL24072614 | 0.78 | SRC (0.54) | ADKFLT3PIK3CDPRKDCDYRK1A | |
| SCHEMBL14643108 | 0.77 | ADK (0.42) | ADKFLT3DYRK1AMAP4K4PRKACA | |
| SCHEMBL26831072 | 0.77 | RPS6KB1 (0.47) | ADKFLT3PIK3CDPRKDCDYRK1A | |
| SCHEMBL24072107 | 0.75 | RET (0.54) | ADKFLT3DYRK1AMAP4K4PRKACA | |
| SCHEMBL23885181 | 0.75 | ADK (0.43) | ADKFLT3DYRK1AMAP4K4PRKACA | |
| SCHEMBL14643788 | 0.75 | SRC (0.47) | ADKFLT3PIK3CDPRKDCDYRK1A | |
| SCHEMBL19264025 | 0.75 | ACACB (0.44) | ADKPIK3CDPRKDCABL1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |