Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.42 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.42 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182244 | 0.89 | ADK (0.35) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL20182346 | 0.82 | SRC (0.35) | FLT3 | |
| SCHEMBL3264036 | 0.76 | DYRK3 (0.49) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL20162777 | 0.69 | FLT3 (0.40) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL23885307 | 0.68 | DYRK3 (0.58) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL16236417 | 0.68 | DYRK3 (0.58) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL23885190 | 0.66 | DYRK3 (0.50) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL22556099 | 0.66 | ACACB (0.39) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL8441851 | 0.65 | DYRK3 (0.54) | DYRK3ROCK2PRKD3MAP4K4PHKG2 | |
| SCHEMBL3782622 | 0.65 | DYRK3 (0.59) | DYRK3ROCK2PRKD3MAP4K4PHKG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |