Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.35 |
| ▸ | LCK | P06239 | 3/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 4/20 | 0.33 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 4/20 | 0.32 |
| ▸ | ABL1 | P00519 | 3/20 | 0.32 |
| ▸ | ABL2 | P42684 | 3/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182213 | 0.84 | SRC (0.42) | SRCLCKTEKEGFREIF2AK3 | |
| SCHEMBL20163166 | 0.82 | SRC (0.43) | SRCLCKTEKEGFREIF2AK3 | |
| SCHEMBL20182344 | 0.82 | DYRK3 (0.42) | FLT3 | |
| SCHEMBL20162794 | 0.76 | SRC (0.37) | SRCLCKTEKEGFREIF2AK3 | |
| SCHEMBL20182244 | 0.73 | ADK (0.35) | FLT3 | |
| SCHEMBL20173329 | 0.71 | EIF2AK3 (0.38) | SRCLCKTEKEIF2AK3 | |
| SCHEMBL20162829 | 0.69 | SRC (0.38) | SRCLCKTEKEGFRFLT3 | |
| SCHEMBL20162919 | 0.68 | SRC (0.42) | SRCLCKTEKEGFREIF2AK3 | |
| SCHEMBL26106229 | 0.68 | SRC (0.42) | SRCLCKTEKEGFRBTK | |
| SCHEMBL30582552 | 0.68 | SRC (0.42) | SRCLCKTEKEGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |