Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.41 |
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | TEK | Q02763 | 7/20 | 0.41 |
| ▸ | LCK | P06239 | 5/20 | 0.41 |
| ▸ | ABL1 | P00519 | 5/20 | 0.40 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | ABL2 | P42684 | 5/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182284 | 0.79 | PIK3CD (0.44) | SRCKDRTEKLCKPIK3CD | |
| SCHEMBL20182228 | 0.71 | KDR (0.45) | SRCKDRTEKLCKEGFR | |
| SCHEMBL13020100 | 0.71 | KDR (0.68) | SRCKDRTEKLCKPIK3CD | |
| SCHEMBL20162848 | 0.71 | SRC (0.45) | SRCKDRTEKLCKABL1 | |
| SCHEMBL20181912 | 0.70 | SRC (0.41) | SRCKDRTEKLCKABL1 | |
| SCHEMBL20182200 | 0.70 | KDR (0.39) | SRCKDRTEKLCKPIK3CD | |
| SCHEMBL20181890 | 0.70 | KDR (0.44) | SRCKDRTEKLCKABL1 | |
| SCHEMBL13020018 | 0.70 | SRC (0.54) | SRCKDRTEKLCKABL1 | |
| SCHEMBL20182298 | 0.69 | NEK7 (0.38) | SRCKDRTEKLCKPIK3CD | |
| SCHEMBL20181907 | 0.67 | EGFR (0.35) | SRCKDRTEKLCKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |