Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | QDPR | P09417 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16922689 | 0.85 | MEN1 (0.55) | MEN1KMT2ACNR1QDPRNAMPT | |
| SCHEMBL16920229 | 0.81 | CNR1 (0.55) | MEN1KMT2ACNR1QDPRNAMPT | |
| SCHEMBL21171650 | 0.77 | NAMPT (0.58) | NAMPT | |
| SCHEMBL15867804 | 0.75 | MEN1 (0.44) | MEN1KMT2ACNR1QDPRNAMPT | |
| SCHEMBL17548158 | 0.74 | QDPR (0.58) | MEN1KMT2AQDPRNAMPTCCNT1 | |
| SCHEMBL14023951 | 0.72 | MEN1 (0.44) | MEN1KMT2ACNR1QDPRNAMPT | |
| SCHEMBL14224507 | 0.71 | MAPK1 (0.58) | MEN1KMT2ACNR1QDPRNAMPT | |
| SCHEMBL2606198 | 0.71 | MEN1 (0.40) | MEN1KMT2ACNR1NAMPTMAPK1 | |
| SCHEMBL20026400 | 0.70 | CNR1 (0.43) | MEN1KMT2ACNR1QDPRNAMPT | |
| SCHEMBL2636491 | 0.70 | ALDH1A1 (0.48) | MEN1KMT2AQDPRKHKNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180141906-A1 | INDOLE AND AZAINDOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY | SHIONOGI & CO. , LTD. (JP) | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141906-A1 | INDOLE AND AZAINDOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY | PRKAA1, PRKAA2, PRKAG3 | MEN1 3730/4885KMT2A 576/4885CNR1 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.