Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 3/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.34 |
| ▸ | GLS | O94925 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL697338 | 0.77 | LTB4R (0.47) | GRM7LTB4RLTB4R2MTNR1ASSTR4 | |
| SCHEMBL696876 | 0.77 | LTB4R (0.47) | GRM7LTB4RLTB4R2MTNR1ASSTR4 | |
| SCHEMBL697337 | 0.77 | LTB4R (0.47) | GRM7LTB4RLTB4R2MTNR1ASSTR4 | |
| SCHEMBL696877 | 0.77 | LTB4R (0.47) | GRM7LTB4RLTB4R2MTNR1ASSTR4 | |
| SCHEMBL20182824 | 0.76 | LTB4R (0.56) | GRM7LTB4RLTB4R2MAPTCYP3A4 | |
| SCHEMBL20183002 | 0.74 | GRM7 (0.33) | GRM7LTB4RLTB4R2MTNR1ASSTR4 | |
| SCHEMBL20182869 | 0.72 | AIMP2 (0.56) | GRM7LTB4RLTB4R2MAPTCYP3A4 | |
| SCHEMBL25626141 | 0.70 | LTB4R (0.40) | GRM7LTB4RLTB4R2SSTR4HTR2B | |
| SCHEMBL21542268 | 0.69 | KDM1A (0.44) | GRM7LTB4RLTB4R2SSTR4CYP3A4 | |
| SCHEMBL21542203 | 0.69 | KDM1A (0.44) | GRM7LTB4RLTB4R2SSTR4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018092921-A1 | MGLUR7 AGONIST COMPOUNDS FOR TREATING MGLUR7- REGULATED DISEASES, DISORDERS, OR CONDITIONS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-24 | — | — | WO | disclosed |