Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 4/20 | 0.56 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.56 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | AIMP2 | Q13155 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182869 | 0.90 | AIMP2 (0.56) | LTB4RLTB4R2PSMB5MAPTAIMP2 | |
| SCHEMBL20182774 | 0.86 | PSMB5 (0.52) | LTB4RLTB4R2PSMB5MAPTMEN1 | |
| SCHEMBL20182940 | 0.85 | GRM7 (0.64) | LTB4RLTB4R2PSMB5MAPTAIMP2 | |
| SCHEMBL697338 | 0.84 | LTB4R (0.47) | LTB4RLTB4R2PSMB5GRM7POLB | |
| SCHEMBL697337 | 0.84 | LTB4R (0.47) | LTB4RLTB4R2PSMB5GRM7POLB | |
| SCHEMBL696877 | 0.84 | LTB4R (0.47) | LTB4RLTB4R2PSMB5GRM7POLB | |
| SCHEMBL696876 | 0.84 | LTB4R (0.47) | LTB4RLTB4R2PSMB5GRM7POLB | |
| SCHEMBL20182939 | 0.84 | PSMB5 (0.50) | LTB4RLTB4R2PSMB5MAPTMEN1 | |
| SCHEMBL25626161 | 0.83 | PSMB5 (0.49) | LTB4RLTB4R2PSMB5MAPTMEN1 | |
| SCHEMBL25626141 | 0.79 | LTB4R (0.40) | LTB4RLTB4R2PSMB5GRM7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541812-B1 | MGLUR7 AGONIST COMPOUNDS FOR TREATING MGLUR7- REGULATED DISEASES, DISORDERS, OR CONDITIONS | TAKEDA PHARMACEUTICALS CO (JP) | 2023-06-14 | — | — | EP | disclosed |
| WO-2018092921-A1 | MGLUR7 AGONIST COMPOUNDS FOR TREATING MGLUR7- REGULATED DISEASES, DISORDERS, OR CONDITIONS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-24 | — | — | WO | disclosed |