Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1494287 | 0.89 | RXFP1 (0.45) | RXFP1PDE10AKMT2ACYP11B1CYP11B2 | |
| SCHEMBL22894327 | 0.81 | CYP11B1 (0.40) | KMT2ACYP11B1CYP11B2TDP1L3MBTL1 | |
| SCHEMBL2149619 | 0.80 | RXFP1 (0.40) | RXFP1PDE10AKMT2ALMNATHRB | |
| SCHEMBL27434483 | 0.78 | RXFP1 (0.56) | RXFP1PDE10AKMT2ACYP11B1CYP11B2 | |
| SCHEMBL30954136 | 0.78 | RXFP1 (0.56) | RXFP1PDE10AKMT2ACYP11B1CYP11B2 | |
| SCHEMBL30954097 | 0.77 | POLB (0.47) | RXFP1PDE10AKMT2ACYP11B1CYP11B2 | |
| SCHEMBL27432476 | 0.77 | RXFP1 (0.46) | RXFP1PDE10AKMT2ACYP11B1CYP11B2 | |
| SCHEMBL27433242 | 0.77 | POLB (0.47) | RXFP1PDE10AKMT2ACYP11B1CYP11B2 | |
| SCHEMBL1494271 | 0.75 | RXFP1 (0.46) | RXFP1PDE10AKMT2ALMNATHRB | |
| SCHEMBL22420325 | 0.74 | PDE10A (0.47) | RXFP1PDE10AKMT2ACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180141919-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | ROCHE PALO ALTO LLC (US) | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141919-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | P2RX3, P2RX6, P2RX2 | RXFP1 145/4885PDE10A 802/4885KMT2A 3706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.