SCHEMBL20183469

SCHEMBL20183469

COc1ccc(-c2ccc(CNc3cccc(F)c3)cc2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.60
MEN1 O00255 3/20 0.60
KMT2A Q03164 3/20 0.60
L3MBTL1 Q9Y468 3/20 0.55
ALDH1A1 P00352 3/20 0.55
CYP1A2 P05177 1/20 0.55
CYP2D6 P10635 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2C19 P33261 1/20 0.55
NPC1 O15118 2/20 0.55
RAB9A P51151 2/20 0.55
LMNA P02545 1/20 0.55
GAA P10253 3/20 0.53
USP2 O75604 1/20 0.53
ALOX15 P16050 1/20 0.53
ALOX12 P18054 1/20 0.53
HSD17B10 Q99714 1/20 0.53
HPGD P15428 2/20 0.53
PPARA Q07869 2/20 0.51
HDAC1 Q13547 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2079779 0.96 MAPT (0.64) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL11512757 0.83 FFAR1 (0.57) MAPTMEN1KMT2ALMNAHPGD
SCHEMBL20183484 0.83 MAPT (0.55) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL10055035 0.83 HPGD (0.67) MAPTMEN1KMT2AALDH1A1LMNA
SCHEMBL20183670 0.82 HDAC1 (0.55) MAPTL3MBTL1ALDH1A1NPC1RAB9A
SCHEMBL17605113 0.82 MEN1 (0.64) MAPTMEN1KMT2AL3MBTL1NPC1
SCHEMBL14689659 0.82 MAPT (0.64) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL20183471 0.82 HIF1A (0.68) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL30480895 0.82 MAPT (0.64) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL21722571 0.79 MAPT (0.65) MAPTMEN1KMT2AL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3327001-B1 NOVEL COMPOUND HAVING BLT INHIBITORY ACTIVITY AND COMPOSITION, FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, COMPRISING SAME AS ACTIVE INGREDIENT UNIV DONGGUK IND ACAD COOP (KR) 2022-04-13 EP disclosed
US-20180215706-A1 NOVEL COMPOUND HAVING BLT INHIBITORY ACTIVITY AND COMPOSITION, FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, COMPRISING SAME AS ACTIVE INGREDIENT DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) 2018-08-02 US disclosed
EP-3327001-A1 NOVEL COMPOUND HAVING BLT INHIBITORY ACTIVITY AND COMPOSITION, FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, COMPRISING SAME AS ACTIVE INGREDIENT Dongguk University Industry-Academic Cooperation Foundation (KR) 2018-05-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180215706-A1 NOVEL COMPOUND HAVING BLT INHIBITORY ACTIVITY AND COMPOSITION, FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, COMPRISING SAME AS ACTIVE INGREDIENT LTB4R2, CYSLTR2, LTB4R MAPT 969/4885MEN1 3684/4885KMT2A 1026/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.