Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | PPARA | Q07869 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14689659 | 0.87 | MAPT (0.64) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL30480895 | 0.87 | MAPT (0.64) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL27734845 | 0.85 | MAPT (0.66) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL10055018 | 0.83 | NOS1 (0.63) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL10267340 | 0.83 | MAPT (0.68) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL701987 | 0.83 | NLRP3 (0.62) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL16966286 | 0.83 | MAPT (0.59) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL14808999 | 0.83 | MAPT (0.67) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL17602062 | 0.83 | NPC1 (0.65) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL2079779 | 0.83 | MAPT (0.64) | MAPTNPC1RAB9AL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024083168-A1 | OXAZEPINE COMPOUNDS COMPRISING A 6-AZA MOIETY AND USES THEREOF | GENENTECH, INC. (US) | 2024-04-25 | — | — | WO | disclosed |
| CN-117736226-A | pan-KRAS inhibitors and their use in medicine | 贝达药业股份有限公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-112119075-B | Condensed ring compound | 豪夫迈·罗氏有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117586280-A | KRAS G12D inhibitor and application thereof in medicine | 贝达药业股份有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-117083279-A | Oxazepine compounds and their use in the treatment of cancer | 基因泰克公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-112119075-A | Fused ring compound | 豪夫迈·罗氏有限公司 | 2020-12-22 | — | — | CN | disclosed |
| EP-3746436-A1 | FUSED RING COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2020-12-09 | — | — | EP | disclosed |
| WO-2020035031-A1 | FUSED RING COMPOUNDS | GENENTECH, INC. (US) | 2020-02-20 | — | — | WO | disclosed |