Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.43 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184276 | 0.86 | P2RX7 (0.49) | P2RX7 | |
| SCHEMBL18880721 | 0.84 | P2RX7 (0.47) | P2RX7CREBBPPDE10APDE4D | |
| SCHEMBL21819349 | 0.69 | P2RX7 (0.67) | P2RX7CREBBP | |
| SCHEMBL6294533 | 0.64 | P2RX7 (0.54) | P2RX7ALDH1A1KMT2AMAPK1 | |
| SCHEMBL21818604 | 0.64 | P2RX7 (0.59) | P2RX7MAPK1 | |
| SCHEMBL11982661 | 0.63 | P2RX7 (0.52) | P2RX7ALDH1A1KMT2AMAPK1 | |
| SCHEMBL8064260 | 0.63 | PTGER1 (0.46) | NSD3ALDH1A1BRAFMAPK3MAPK1 | |
| SCHEMBL21819399 | 0.63 | P2RX7 (0.64) | P2RX7SMN1; SMN2 | |
| SCHEMBL21863402 | 0.62 | POLB (0.46) | P2RX7KMT2AGAA | |
| SCHEMBL10326542 | 0.60 | P2RX7 (0.54) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970267-B3 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-30 | — | — | EP | claimed |
| EP-2970267-B3 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-30 | — | — | EP | disclosed |