Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28612255 | 0.88 | P2RX7 (0.53) | P2RX7HTR2AHTR2CHTR2B | |
| SCHEMBL20184312 | 0.86 | P2RX7 (0.43) | P2RX7 | |
| SCHEMBL18880721 | 0.81 | P2RX7 (0.47) | P2RX7 | |
| SCHEMBL29844044 | 0.74 | HTR2A (0.39) | P2RX7HTR2AHTR2CHTR2B | |
| SCHEMBL16089602 | 0.70 | HTR2A (0.56) | HTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL16037607 | 0.69 | P2RX7 (0.83) | P2RX7 | |
| Hydrochloric Acid SCHEMBL16037283 | 0.69 | HTR2A (0.55) | HTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL16089605 | 0.69 | P2RX7 (0.78) | P2RX7 | |
| SCHEMBL21819349 | 0.68 | P2RX7 (0.67) | P2RX7DPP4DPP8DPP7 | |
| SCHEMBL16036259 | 0.67 | P2RX7 (1.00) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970267-B3 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-30 | — | — | EP | claimed |