Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.55 |
| ▸ | JAK2 | O60674 | 12/20 | 0.55 |
| ▸ | STK3 | Q13188 | 2/20 | 0.51 |
| ▸ | STK4 | Q13043 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
| ▸ | CDC7 | O00311 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184546 | 0.87 | JAK3 (0.60) | JAK3JAK2JAK1 | |
| SCHEMBL20184692 | 0.86 | JAK3 (0.70) | JAK3JAK2JAK1 | |
| SCHEMBL20184531 | 0.86 | JAK3 (0.56) | JAK3JAK2JAK1 | |
| SCHEMBL20184499 | 0.86 | JAK2 (0.54) | JAK3JAK2STK3LRRK2CDC7 | |
| SCHEMBL20184432 | 0.85 | JAK3 (0.68) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184721 | 0.85 | JAK3 (0.73) | JAK3JAK2JAK1 | |
| SCHEMBL20184458 | 0.85 | JAK3 (0.71) | JAK3JAK2ROCK2LIMK1JAK1 | |
| SCHEMBL20184385 | 0.85 | JAK3 (0.71) | JAK3JAK2STK3STK4LRRK2 | |
| SCHEMBL16245011 | 0.83 | JAK3 (0.80) | JAK3JAK2JAK1 | |
| SCHEMBL20184454 | 0.83 | JAK3 (0.70) | JAK3JAK2ROCK2LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |