Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.51 |
| ▸ | JAK3 | P52333 | 13/20 | 0.51 |
| ▸ | CHUK | O15111 | 4/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184527 | 0.89 | JAK2 (0.49) | JAK2JAK3CHUKIKBKBHSP90AB1 | |
| SCHEMBL20184489 | 0.89 | JAK2 (0.51) | JAK2JAK3 | |
| SCHEMBL20184337 | 0.89 | JAK2 (0.43) | JAK2JAK3CHUKIKBKBHSP90AB1 | |
| SCHEMBL20184525 | 0.89 | JAK2 (0.49) | JAK2JAK3CHUK | |
| SCHEMBL20184357 | 0.88 | CHUK (0.47) | JAK2JAK3CHUK | |
| SCHEMBL20184700 | 0.88 | JAK2 (0.40) | JAK2JAK3 | |
| SCHEMBL20184555 | 0.88 | HSP90AB1 (0.43) | JAK2JAK3CHUKADORA2AHSP90AB1 | |
| SCHEMBL20184581 | 0.86 | JAK3 (0.43) | JAK2JAK3 | |
| SCHEMBL20184582 | 0.86 | JAK2 (0.52) | JAK2JAK3HSP90AB1 | |
| SCHEMBL20184673 | 0.86 | JAK2 (0.53) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |