Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 10/20 | 0.41 |
| ▸ | JAK3 | P52333 | 10/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | CDC7 | O00311 | 3/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | PRKACA | P17612 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184417 | 0.88 | DYRK1A (0.45) | JAK2JAK3PIM1CDC7PIM3 | |
| SCHEMBL20184387 | 0.87 | GPR84 (0.45) | JAK2JAK3CAMKK2 | |
| SCHEMBL20184527 | 0.87 | JAK2 (0.49) | CHUKJAK2JAK3CAMKK2 | |
| SCHEMBL20184489 | 0.87 | JAK2 (0.51) | JAK2JAK3AXLPRKAA1CAMKK2 | |
| SCHEMBL20184337 | 0.87 | JAK2 (0.43) | CHUKJAK2JAK3PRKAA1 | |
| SCHEMBL20184525 | 0.87 | JAK2 (0.49) | CHUKJAK2JAK3AXLPRKAA1 | |
| SCHEMBL20184517 | 0.86 | CYP3A4 (0.40) | JAK2JAK3ABL1AXLCSNK2A1 | |
| SCHEMBL20184555 | 0.86 | HSP90AB1 (0.43) | CHUKJAK2JAK3PDE4BCAMKK2 | |
| SCHEMBL20184700 | 0.86 | JAK2 (0.40) | JAK2JAK3PRKAA1 | |
| SCHEMBL20184538 | 0.84 | JAK2 (0.39) | JAK2JAK3CDC7MAP4K4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |