Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.40 |
| ▸ | JAK3 | P52333 | 9/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | CDH1 | P12830 | 1/20 | 0.36 |
| ▸ | APC | P25054 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184337 | 0.89 | JAK2 (0.43) | JAK2JAK3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184489 | 0.89 | JAK2 (0.51) | JAK2JAK3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184527 | 0.89 | JAK2 (0.49) | JAK2JAK3DHODHPLTP | |
| SCHEMBL20184525 | 0.89 | JAK2 (0.49) | JAK2JAK3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184555 | 0.88 | HSP90AB1 (0.43) | JAK2JAK3DHODH | |
| SCHEMBL20184478 | 0.86 | JAK2 (0.53) | JAK2JAK3DHODH | |
| SCHEMBL20184357 | 0.86 | CHUK (0.47) | JAK2JAK3PRKAA1 | |
| SCHEMBL20184673 | 0.86 | JAK2 (0.53) | JAK2JAK3PTGDR2PRKAB2PRKAG1 | |
| SCHEMBL20184538 | 0.86 | JAK2 (0.39) | JAK2JAK3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184582 | 0.86 | JAK2 (0.52) | JAK2JAK3PTGDR2PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |