Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.56 |
| ▸ | JAK2 | O60674 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15032941 | 0.88 | JAK3 (0.76) | JAK3JAK2JAK1 | |
| SCHEMBL16245316 | 0.88 | JAK3 (0.76) | JAK3JAK2JAK1 | |
| SCHEMBL20184366 | 0.85 | JAK3 (0.59) | JAK3JAK2JAK1 | |
| SCHEMBL20184714 | 0.84 | JAK3 (0.76) | JAK3JAK2JAK1 | |
| SCHEMBL20184573 | 0.84 | JAK3 (0.76) | JAK3JAK2JAK1 | |
| SCHEMBL20184388 | 0.84 | RAB9A (0.50) | JAK3JAK2MEN1RAB9AKMT2A | |
| SCHEMBL20184558 | 0.84 | JAK3 (0.77) | JAK3JAK2JAK1 | |
| SCHEMBL20184485 | 0.84 | JAK3 (0.77) | JAK3JAK2JAK1 | |
| SCHEMBL20184364 | 0.83 | JAK3 (0.77) | JAK3JAK2JAK1 | |
| SCHEMBL15010428 | 0.82 | JAK3 (0.60) | JAK3JAK2RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |