Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | MEN1 | O00255 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | POLB | P06746 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 8/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184521 | 0.86 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184508 | 0.86 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184704 | 0.85 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184539 | 0.85 | JAK3 (0.51) | JAK3JAK2 | |
| SCHEMBL20184322 | 0.85 | JAK3 (0.62) | MEN1KMT2AJAK3JAK2CYP1A2 | |
| SCHEMBL20184418 | 0.84 | JAK3 (0.64) | JAK3JAK2TP53BP1 | |
| SCHEMBL20184428 | 0.84 | JAK3 (0.56) | RAB9AMEN1KMT2APOLBNPC1 | |
| SCHEMBL20184530 | 0.84 | JAK3 (0.49) | RAB9AMEN1KMT2APOLBNPC1 | |
| SCHEMBL20184567 | 0.83 | JAK3 (0.58) | JAK3JAK2 | |
| SCHEMBL20184557 | 0.83 | JAK3 (0.47) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |