Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 20/20 | 0.54 |
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15032740 | 0.87 | JAK3 (0.73) | JAK3JAK2JAK1 | |
| SCHEMBL15010792 | 0.87 | JAK3 (0.62) | JAK3JAK2JAK1 | |
| SCHEMBL20184365 | 0.86 | JAK3 (0.58) | JAK3JAK2JAK1 | |
| SCHEMBL20184425 | 0.84 | JAK3 (0.59) | JAK3JAK2JAK1 | |
| SCHEMBL20184694 | 0.83 | JAK3 (0.47) | JAK3JAK2JAK1 | |
| SCHEMBL20184477 | 0.81 | JAK3 (0.76) | JAK3JAK2JAK1 | |
| SCHEMBL20184457 | 0.81 | JAK3 (0.77) | JAK3JAK2JAK1 | |
| SCHEMBL20184492 | 0.80 | JAK3 (0.77) | JAK3JAK2JAK1 | |
| SCHEMBL20184544 | 0.80 | JAK3 (0.69) | JAK3JAK2JAK1 | |
| SCHEMBL20184703 | 0.80 | LRRK2 (0.53) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |