Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.47 |
| ▸ | JAK2 | O60674 | 5/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184481 | 0.89 | CYP3A4 (0.48) | JAK3JAK2HSD17B10JAK1CYP3A4 | |
| SCHEMBL20184323 | 0.88 | JAK3 (0.41) | JAK3JAK2JAK1 | |
| SCHEMBL20184688 | 0.88 | JAK3 (0.43) | JAK3JAK2JAK1 | |
| SCHEMBL20184594 | 0.86 | JAK3 (0.43) | JAK3JAK2JAK1 | |
| SCHEMBL20184567 | 0.83 | JAK3 (0.58) | JAK3JAK2BTKJAK1 | |
| SCHEMBL16245166 | 0.83 | JAK3 (0.58) | JAK3JAK2JAK1 | |
| SCHEMBL20184429 | 0.83 | JAK3 (0.54) | JAK3JAK2JAK1 | |
| SCHEMBL20184677 | 0.82 | F11 (0.43) | JAK3JAK2 | |
| SCHEMBL20184584 | 0.82 | JAK3 (0.59) | JAK3JAK2JAK1 | |
| SCHEMBL20184508 | 0.82 | JAK3 (0.59) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |