Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.53 |
| ▸ | JAK2 | O60674 | 7/20 | 0.52 |
| ▸ | JAK3 | P52333 | 7/20 | 0.52 |
| ▸ | MST1 | P26927 | 1/20 | 0.48 |
| ▸ | STK4 | Q13043 | 1/20 | 0.48 |
| ▸ | STK3 | Q13188 | 1/20 | 0.48 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184671 | 0.85 | JAK3 (0.52) | JAK2JAK3 | |
| SCHEMBL15032688 | 0.84 | JAK3 (0.76) | JAK2JAK3 | |
| SCHEMBL20184531 | 0.83 | JAK3 (0.56) | JAK2JAK3 | |
| SCHEMBL20184692 | 0.83 | JAK3 (0.70) | JAK2JAK3 | |
| SCHEMBL20184432 | 0.82 | JAK3 (0.68) | JAK2JAK3 | |
| SCHEMBL20184385 | 0.82 | JAK3 (0.71) | LRRK2JAK2JAK3STK4STK3 | |
| SCHEMBL20184458 | 0.82 | JAK3 (0.71) | JAK2JAK3 | |
| SCHEMBL20184353 | 0.82 | JAK3 (0.55) | LRRK2JAK2JAK3STK4STK3 | |
| SCHEMBL20184721 | 0.82 | JAK3 (0.73) | JAK2JAK3 | |
| SCHEMBL20184448 | 0.82 | JAK3 (0.46) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |