Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.75 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | ITK | Q08881 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184689 | 0.88 | JAK3 (0.78) | JAK3JAK2 | |
| SCHEMBL15032934 | 0.86 | JAK3 (1.00) | JAK3JAK2 | |
| SCHEMBL20184574 | 0.85 | JAK3 (0.79) | JAK3JAK2BTK | |
| SCHEMBL20184571 | 0.85 | JAK3 (0.77) | JAK3 | |
| SCHEMBL20184601 | 0.82 | JAK3 (0.59) | JAK3JAK2BTKITK | |
| SCHEMBL20184457 | 0.81 | JAK3 (0.77) | JAK3JAK2 | |
| SCHEMBL20184596 | 0.80 | JAK3 (0.71) | JAK3JAK2 | |
| SCHEMBL20184385 | 0.77 | JAK3 (0.71) | JAK3JAK2 | |
| SCHEMBL20184720 | 0.76 | JAK3 (0.77) | JAK3JAK2BTKITK | |
| SCHEMBL20184363 | 0.76 | JAK3 (0.55) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |