Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.71 |
| ▸ | JAK2 | O60674 | 17/20 | 0.71 |
| ▸ | KMO | O15229 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184409 | 0.85 | JAK3 (0.55) | JAK3JAK2 | |
| SCHEMBL20184362 | 0.85 | JAK3 (0.74) | JAK3JAK2 | |
| SCHEMBL15032886 | 0.83 | JAK3 (1.00) | JAK3JAK2 | |
| SCHEMBL20184434 | 0.83 | JAK3 (0.74) | JAK3JAK2 | |
| SCHEMBL20184363 | 0.83 | JAK3 (0.55) | JAK3JAK2 | |
| SCHEMBL20184346 | 0.82 | JAK2 (0.67) | JAK3JAK2 | |
| SCHEMBL20184385 | 0.81 | JAK3 (0.71) | JAK3JAK2KMO | |
| SCHEMBL20184433 | 0.80 | JAK3 (0.75) | JAK3JAK2 | |
| SCHEMBL20184531 | 0.80 | JAK3 (0.56) | JAK3JAK2 | |
| SCHEMBL20184679 | 0.80 | JAK3 (0.56) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |