Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.77 |
| ▸ | JAK2 | O60674 | 4/20 | 0.52 |
| ▸ | BTK | Q06187 | 9/20 | 0.51 |
| ▸ | BMX | P51813 | 2/20 | 0.51 |
| ▸ | TEC | P42680 | 1/20 | 0.47 |
| ▸ | TXK | P42681 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16245183 | 0.87 | JAK3 (1.00) | JAK3JAK2 | |
| SCHEMBL20184510 | 0.87 | JAK3 (0.59) | JAK3BTKJAK1 | |
| SCHEMBL20184325 | 0.82 | JAK3 (0.59) | JAK3JAK2BTKBMXTEC | |
| SCHEMBL20184689 | 0.80 | JAK3 (0.78) | JAK3JAK2 | |
| SCHEMBL20184457 | 0.78 | JAK3 (0.77) | JAK3JAK2JAK1 | |
| SCHEMBL20184436 | 0.77 | JAK3 (0.57) | JAK3JAK2BTK | |
| SCHEMBL20184433 | 0.76 | JAK3 (0.75) | JAK3JAK2BTKITK | |
| SCHEMBL20184574 | 0.76 | JAK3 (0.79) | JAK3JAK2BTK | |
| SCHEMBL20184606 | 0.76 | JAK3 (0.55) | JAK3JAK1 | |
| SCHEMBL15032930 | 0.75 | JAK3 (0.78) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |