Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.34 |
| ▸ | CDK9 | P50750 | 3/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15032649 | 0.89 | ALDH1A1 (0.38) | LMNAALDH1A1DNPH1SMN1; SMN2KMT2A | |
| SCHEMBL15032831 | 0.89 | ALDH1A1 (0.38) | LMNAALDH1A1DNPH1SMN1; SMN2RAB9A | |
| SCHEMBL15009804 | 0.89 | ALDH1A1 (0.42) | LMNAALDH1A1DNPH1SMN1; SMN2NPC1 | |
| SCHEMBL15032820 | 0.87 | PDE4A (0.42) | ALDH1A1SMN1; SMN2RAB9AKMT2AMEN1 | |
| SCHEMBL15013994 | 0.87 | ALDH1A1 (0.36) | LMNAALDH1A1DNPH1KMT2AMEN1 | |
| SCHEMBL15032868 | 0.86 | ALDH1A1 (0.36) | LMNAALDH1A1DNPH1SMN1; SMN2NPC1 | |
| SCHEMBL15032650 | 0.84 | ALDH1A1 (0.43) | LMNAALDH1A1DNPH1KMT2AMEN1 | |
| SCHEMBL16245216 | 0.84 | ALDH1A1 (0.41) | LMNAALDH1A1DNPH1KMT2AMEN1 | |
| SCHEMBL15032806 | 0.83 | DNPH1 (0.38) | ALDH1A1DNPH1KMT2AMEN1MAPT | |
| SCHEMBL15032969 | 0.81 | MAPT (0.37) | LMNAALDH1A1DNPH1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | disclosed |