Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.50 |
| ▸ | JAK2 | O60674 | 14/20 | 0.50 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15032732 | 0.83 | JAK3 (0.74) | JAK3JAK2 | |
| SCHEMBL20184458 | 0.82 | JAK3 (0.71) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184686 | 0.82 | JAK3 (0.55) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184531 | 0.81 | JAK3 (0.56) | JAK3JAK2 | |
| SCHEMBL20184346 | 0.80 | JAK2 (0.67) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184554 | 0.79 | JAK3 (0.39) | JAK3JAK2LDHA | |
| SCHEMBL20184535 | 0.79 | JAK3 (0.76) | JAK3 | |
| SCHEMBL20184409 | 0.79 | JAK3 (0.55) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184432 | 0.77 | JAK3 (0.68) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184678 | 0.77 | JAK3 (0.51) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |