Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.39 |
| ▸ | JAK2 | O60674 | 14/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | MATK | P42679 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184581 | 0.83 | JAK3 (0.43) | JAK3JAK2 | |
| SCHEMBL20184599 | 0.83 | JAK3 (0.53) | JAK3JAK2HSP90AB1CHUK | |
| SCHEMBL20184398 | 0.83 | JAK2 (0.51) | JAK3JAK2HSP90AB1CHUK | |
| SCHEMBL20184555 | 0.83 | HSP90AB1 (0.43) | JAK3JAK2HSP90AB1CHUKDYRK1A | |
| SCHEMBL20184408 | 0.82 | JAK3 (0.43) | JAK3JAK2HSP90AB1 | |
| SCHEMBL20184529 | 0.81 | JAK3 (0.59) | JAK3 | |
| SCHEMBL20184670 | 0.80 | HSP90AB1 (0.42) | JAK3JAK2HSP90AB1CHUK | |
| SCHEMBL20184488 | 0.79 | JAK3 (0.50) | JAK3JAK2LDHA | |
| SCHEMBL20184525 | 0.79 | JAK2 (0.49) | JAK3JAK2CHUK | |
| SCHEMBL20184377 | 0.78 | JAK3 (0.56) | JAK3JAK2HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |