Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 10/20 | 0.49 |
| ▸ | JAK2 | O60674 | 4/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184588 | 0.86 | MMP2 (0.52) | MAPTLMNAMEN1KMT2AJAK3 | |
| SCHEMBL20184334 | 0.86 | JAK3 (0.64) | MAPTLMNAMEN1KMT2AJAK3 | |
| SCHEMBL20184370 | 0.86 | MMP1 (0.50) | MAPTLMNAMEN1KMT2AJAK3 | |
| SCHEMBL20184572 | 0.85 | JAK3 (0.61) | MAPTLMNAMEN1KMT2AJAK3 | |
| SCHEMBL20184508 | 0.85 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184521 | 0.85 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184418 | 0.85 | JAK3 (0.64) | JAK3JAK2 | |
| SCHEMBL20184523 | 0.84 | JAK3 (0.62) | JAK3JAK2 | |
| SCHEMBL20184704 | 0.84 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184539 | 0.84 | JAK3 (0.51) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |