Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.39 |
| ▸ | JAK3 | P52333 | 10/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184415 | 0.90 | JAK2 (0.38) | JAK2JAK3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184400 | 0.88 | JAK3 (0.39) | JAK2JAK3SGK1CAMKK2 | |
| SCHEMBL20184527 | 0.87 | JAK2 (0.49) | JAK2JAK3PARP1HSP90AB1SGK1 | |
| SCHEMBL20184489 | 0.87 | JAK2 (0.51) | JAK2JAK3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184337 | 0.87 | JAK2 (0.43) | JAK2JAK3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184525 | 0.87 | JAK2 (0.49) | JAK2JAK3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184700 | 0.86 | JAK2 (0.40) | JAK2JAK3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184555 | 0.86 | HSP90AB1 (0.43) | JAK2JAK3HSP90AB1SGK1CAMKK2 | |
| SCHEMBL20184673 | 0.84 | JAK2 (0.53) | JAK2JAK3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184582 | 0.84 | JAK2 (0.52) | JAK2JAK3PRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |