Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.38 |
| ▸ | JAK3 | P52333 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184538 | 0.90 | JAK2 (0.39) | JAK2JAK3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184555 | 0.87 | HSP90AB1 (0.43) | JAK2JAK3MAPTDHODH | |
| SCHEMBL20184527 | 0.86 | JAK2 (0.49) | JAK2JAK3DHODH | |
| SCHEMBL20184489 | 0.86 | JAK2 (0.51) | JAK2JAK3DHODHPRKAB2PRKAG1 | |
| SCHEMBL20184337 | 0.86 | JAK2 (0.43) | JAK2JAK3MAPTPRKAB2PRKAG1 | |
| SCHEMBL20184525 | 0.86 | JAK2 (0.49) | JAK2JAK3POLBPRKAB2PRKAG1 | |
| SCHEMBL20184700 | 0.85 | JAK2 (0.40) | JAK2JAK3DHODHPRKAB2PRKAG1 | |
| SCHEMBL20184398 | 0.85 | JAK2 (0.51) | JAK2JAK3 | |
| SCHEMBL20184582 | 0.83 | JAK2 (0.52) | JAK2JAK3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184673 | 0.83 | JAK2 (0.53) | JAK2JAK3MAPTTP53PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |