Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.52 |
| ▸ | JAK3 | P52333 | 17/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184540 | 0.85 | JAK2 (0.51) | JAK2JAK3KDM4EMEN1HSP90AA1 | |
| SCHEMBL20184461 | 0.85 | JAK3 (0.69) | JAK2JAK3KDM4EMEN1HSP90AA1 | |
| SCHEMBL20184436 | 0.85 | JAK3 (0.57) | JAK2JAK3ROCK2LIMK1 | |
| SCHEMBL20184432 | 0.83 | JAK3 (0.68) | JAK2JAK3ROCK2LIMK1 | |
| SCHEMBL15032793 | 0.82 | JAK3 (0.78) | JAK2JAK3 | |
| SCHEMBL20184454 | 0.81 | JAK3 (0.70) | JAK2JAK3ROCK2LIMK1 | |
| SCHEMBL20184346 | 0.78 | JAK2 (0.67) | JAK2JAK3ROCK2LIMK1 | |
| SCHEMBL20184389 | 0.78 | JAK3 (0.40) | JAK2JAK3HSP90AB1 | |
| SCHEMBL20184678 | 0.77 | JAK3 (0.51) | JAK2JAK3LRRK2 | |
| SCHEMBL20184531 | 0.76 | JAK3 (0.56) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |