Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.57 |
| ▸ | JAK2 | O60674 | 14/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 2/20 | 0.45 |
| ▸ | STK4 | Q13043 | 1/20 | 0.44 |
| ▸ | STK3 | Q13188 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184579 | 0.85 | JAK2 (0.52) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL27741653 | 0.85 | HSP90AB1 (0.61) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184461 | 0.84 | JAK3 (0.69) | JAK3JAK2ROCK2LIMK1BTK | |
| SCHEMBL20184540 | 0.84 | JAK2 (0.51) | JAK3JAK2BTK | |
| SCHEMBL16245251 | 0.84 | JAK3 (0.80) | JAK3JAK2 | |
| SCHEMBL20184432 | 0.82 | JAK3 (0.68) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184454 | 0.80 | JAK3 (0.70) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184510 | 0.79 | JAK3 (0.59) | JAK3BTK | |
| SCHEMBL20184701 | 0.78 | JAK2 (0.61) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184405 | 0.78 | HSP90AB1 (0.45) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |