Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.60 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | BLK | P51451 | 1/20 | 0.35 |
| ▸ | BMX | P51813 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184601 | 0.90 | JAK3 (0.59) | JAK3JAK2BTKITK | |
| SCHEMBL20184585 | 0.88 | JAK3 (0.61) | JAK3JAK2BTK | |
| SCHEMBL20184684 | 0.87 | JAK3 (0.60) | JAK3 | |
| SCHEMBL20184356 | 0.86 | JAK3 (0.51) | JAK3JAK2HSP90AB1 | |
| SCHEMBL20184567 | 0.84 | JAK3 (0.58) | JAK3JAK2BTKITK | |
| SCHEMBL20184689 | 0.82 | JAK3 (0.78) | JAK3JAK2 | |
| SCHEMBL20184325 | 0.82 | JAK3 (0.59) | JAK3JAK2HSP90AB1BTKITK | |
| SCHEMBL20184464 | 0.81 | JAK3 (0.39) | JAK3JAK2HSP90AB1 | |
| SCHEMBL20184377 | 0.81 | JAK3 (0.56) | JAK3JAK2HSP90AB1 | |
| SCHEMBL20184337 | 0.78 | JAK2 (0.43) | JAK3JAK2HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |