Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 7/20 | 0.61 |
| ▸ | BTK | Q06187 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184586 | 0.88 | JAK3 (0.60) | JAK3BTKJAK2 | |
| SCHEMBL20184333 | 0.88 | JAK3 (0.61) | JAK3 | |
| SCHEMBL20184601 | 0.87 | JAK3 (0.59) | JAK3BTKJAK2FGFR4EGFR | |
| SCHEMBL20184574 | 0.83 | JAK3 (0.79) | JAK3BTKJAK2 | |
| SCHEMBL20184567 | 0.81 | JAK3 (0.58) | JAK3BTKJAK2EGFR | |
| SCHEMBL20184325 | 0.78 | JAK3 (0.59) | JAK3BTKJAK2FGFR4 | |
| SCHEMBL20184673 | 0.77 | JAK2 (0.53) | JAK3JAK2 | |
| SCHEMBL16245250 | 0.76 | JAK3 (1.00) | JAK3JAK2 | |
| SCHEMBL20184518 | 0.76 | PRKAB2 (0.48) | JAK3JAK2 | |
| SCHEMBL20184684 | 0.75 | JAK3 (0.60) | JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |