Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.56 |
| ▸ | JAK2 | O60674 | 10/20 | 0.56 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184377 | 0.88 | JAK3 (0.56) | JAK3JAK2 | |
| SCHEMBL20184408 | 0.87 | JAK3 (0.43) | JAK3JAK2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184515 | 0.86 | JAK3 (0.56) | JAK3JAK2MAP4K1 | |
| SCHEMBL20184700 | 0.84 | JAK2 (0.40) | JAK3JAK2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20184536 | 0.84 | JAK3 (0.47) | JAK3JAK2 | |
| SCHEMBL20184581 | 0.83 | JAK3 (0.43) | JAK3JAK2 | |
| SCHEMBL20184478 | 0.83 | JAK2 (0.53) | JAK3JAK2PDE4BPDE4D | |
| SCHEMBL20184524 | 0.81 | JAK3 (0.59) | JAK3 | |
| SCHEMBL20184601 | 0.81 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184672 | 0.81 | JAK2 (0.54) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |